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This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez. Definition: The epithelial cell rests of Malasse are discrete clusters of residual cells from Hertwig’s epithelial root sheath (HERS) that didn’t. The authors performed a PubMed search on the term “epithelial rests” alone or in combination with “Malassez.” Relevant articles were categorized into primary.

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In longitudinal and transverse slices of human specimens, Malassez noted the presence of epithelial cells that persisted around the roots Figs 1, 2 and 3.

Report based on literature review. Sur l’existence damas epitheliaux autour de la racine des dents chez l’homme adulte epitbelial a l’etat normal debris epitheliaux paradentaires. Evolution and development of Hertwig’s epithelial root sheath.

Hyalinization during orthodontic tooth movement: The capacity to repair periodontium and to prevent cementum damages were connected with this process. Tooth development Epithelial cells. Maintenance of a constant periodontal ligament space by indirect stimulation of osteoclast differentiation though decreasing the decoy receptor OPG and increasing Resys Prevention of the formation of alveolodental ankylosis by constantly secreting bone resorptive mediators thereby preventing mineralisation of the periodontal ligament; Participation in the process of periodontal regeneration by providing a stem cell supply which can epiyhelial to sites epirhelial resorption and injury and stimulate cementogenesis; Participation in tooth movement malaxsez increasing EGF production in periodontal tissues and helping to repair root resorption areas while stimulating cementogenesis.

As for the most frequent types of REM, small and differentiated ones decrease with age, while proliferative ones increase with age. Direct stimulation of bone resorption by epidermal growth factor. The prevalence and distribution of rests of Malassez in the mouse molar and their possible role in repair and maintenance of the periodontal ligament.

According to the authors, the ERM were not isolated structures, forming a structure similar to a fishing net around tooth roots Fig 1giving ERM a role in maintaining the periodontal space and preventing alveolodental ankylosis.

Histology, A Text and Atlas. The prevalence, distribution, and morphologic changes of the epithelial remnants in the molar region of the rat. Stem Cells ; The rsets of periodontal tissue occurs through assistance in the renewal of cells that suffered some sort of damage.

Prevention of alveolodental ankylosis Alveolodental ankylosis is characterized by malaswez absence of tooth elastin due to the loss of periodontal ligament cells associated with root resorption.


epithelial cell rests of Malassez

Interestingly, Serres 5 had approached the occurrence of HERS degeneration in the same work that described the enamel organ debris, but did not relate these events with each other.

Mlaassez cell rests of Malassez bind epidermal growth factor intensely. Regulatory mechanisms of periodontal regeneration. Mitotic activity in epithelial epitheloal of Malassez. Collagen plays a key role in supporting the tensile forces; periodontal ligament compression and its renewal are extremely important in maintaining the ligament space and protecting the tissue from mechanical forces.

[Epithelial cell rests of Malassez: tissue, cell, and molecular biology].

Author information Article notes Copyright and License information Disclaimer. Epithelial cell rests of Malassez are functional components of the periodontium that fulfil key physiological and regenerative functions to ensure periodontal integrity. Decades later, Legros and Magiot 6 pointed to the epithelial origin of these remaining cells and suggested that they could be associated with the formation of cysts, as dentigerous cysts and odontomas.

The latter also promote release of bone matrix proteins, BMP-2, osteopontin, osteoprotegerin and sialoprotein, proteins that aid in the repair and periodontal regeneration phase, aside from contributing to the repair of cementum itself. Moreover, an increase in ankylosis events related to the processes and the hyalinization of periodontal tissue after the application of mechanical forces during the aging process can be associated to the potential of ERM.

Epithelial rests of Malassez: from latent cells to active participation in orthodontic movement

Reviews on this topic are infrequent in the dental literature and the notable advances regarding the cytokine profile of the epithelial cell rests of Malassez and their autocrine and paracrine roles in the periodontal tissues make it opportune to review their physiological roles in maintaining periodontal health. Osteoclast formation and differentiation: Proliferation of epithelial rests of Malassez during experimental tooth movement.

This page was last edited on 23 Gestsat The present literature review aims at presenting the potential functions of ERM, with emphasis on orthodontic movement and the functional structure of the periodontium. From these results, articles were selected that were in English, dating fromand were related to this review.

It is considered that these cell rests proliferate to form epithelial lining of various odontogenic cysts such as radicular cyst under the influence of various stimuli.

Epithelial rests of Malassez: from latent cells to active participation in orthodontic movement

Report based on literature review. Find articles by Bianca Silva e Silva. Orthodontic movement, however, does not promote ERM necrosis, but, rather, just the reverse. ERM distributed around the tooth root, forming something like a fishing net.


J Med Dent Sci ; 59 3: The origin and formation of dental follicle. The ERM are resulting from cell fragmentation of the Hertwig epithelial root sheath HERSan apical extent of internal and external epithelial enamel, which stimulates the differentiation of ectomesenchymal cells into odontoblasts, secreting root dentin.

The prevalence, morphology, and distribution of epithelial rests in the human periodontal ligament. From their potential in the context of maintaining periodontal insertion through the release of inflammatory mediator structures, proteins and growth factors, the ERM were identified as key figures in maintaining homeostasis, assisting in the maintenance of space in the periodontal ligament, cementum repair and regeneration processes and collagen renewal.

Such evidence created possibilities for further investigations. The ultrastructural characteristics of these cells provided evidence that they could be involved in mediating cementogenesis in the root resorption process, opening precedence for further research in this direction. Advances in the regulation of osteoclasts and os-teoclast functions.

How to cite this article.

These structures thus came to be known as the “epithelial rests of Malassez”, receiving the eponymous name of its principal investigator. Some rests become calcified in the periodontal ligament cementicles The epithelial cell rests of Malassez ERM are formed by persisting fragments of epithelial sheath Hertwig shaeth that participates in the tooth root development.

Data acquisition, analysis or interpretation: When properly executed, the orthodontic movement is able to stimulate the secretory power of these cells, which prevents the recurrence of ankylosis. From the release of substances and differentiation of its epithelial cells, the remaining ERM play an important role in the formation and repair of cementum, particularly in the differentiation of cementoblasts with mesenchymal origin, preferably through the direct transformation of epithelial cells to cementoblasts.

Orthodontic treatment, in turn, is essentially a periodontal event that involves an acute inflammatory response during its initial phase. Initially described by Serres, 5 these remaining cells of the periodontal ligament are portrayed as enamel organ debris.

Alveolodental ankylosis is characterized by the absence of tooth elastin due to the loss of periodontal ligament cells associated with root resorption.