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EXTRUSION AND SPHERONIZATION PDF

Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.

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The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product. The dry, mixed, extrusjon active substances are kneaded into a dough with a liquid.

The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts. The final drying ensures the pellet hardness.

The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization. This dough then pressed through an extruder.

Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format. Register for An Account Already a member?

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The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing. In other industries, the size of the pellets can be several centimeters.

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Please note that Lonza has updated its Privacy Policy. The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result.

The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the wnd “rope”. Read more about it here! It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release.

Application of Multiparticulate Technologies for Drug Delivery. Please read our updated Cookies Policy for information extrision which cookies we use and the information we collect.

Common applications include delayed release, extended release, pulsatile release, and fixed dose combinations.

Extrusion / Spheronization – Glatt Integrated Process Solutions

Cookies allow us to give you the best browsing experience and help us extrysion understand how you use our site. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating.

Our Mini-tablets are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology.

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The process consists of four process steps: The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert. You can disable cookies but parts of our website may not work.

Extrusion & Spheronization Pharmaceutical Technology

Capsugel offers a drug delivery technology to provide exgrusion delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.

Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on two growing technology options. Primary packaging in either vials or sachets and secondary packaging services are s;heronization available.

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We also use cookies on our websites. For technical reasons, the resulting pellets are larger than micrometers. Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets. For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added.