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ABSTRACT. Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and. Abstract: Inositol hexaphosphate (IP6) is a naturally occur- ring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain. While IP-6 is found in rice bran and other foods, there are good reasons to take an IP-6 & Inositol supplement. First, IP-6 is getter absorbed in pure form without.

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Effects of dietary phytic acid phytate on the incidence and growth rate of tumors promoted in Fisher rats by a magnesium supplement.

The most consistent and best anticancer results were obtained from the combination of IP 6 plus inositol. In addition, IP 6 possesses other significant benefits for human health, such as the ability to enhance immune system, prevent pathological calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity.

It was also hypothesized that the addition of inositol, a precursor of inositol phosphates and also inosito natural carbohydrate, to IP 6 may enhance the anticancer function of IP 6 18 — It was recently recognized to possess multiple biological functions. A reduced tumor growth rate was noticed overall and in some cases a regression of lesions was noted.

Close mobile search navigation Article navigation. They also showed that the levels of IP 6 and its less phosphorylated forms fluctuate depending on the intake of IP 6.

Protection against cancer by dietary IP6 and inositol.

Our recent data demonstrate that IP 6 acts synergistically with doxorubicin and tamoxifen, being insoitol effective against estrogen receptor—negative and doxorubicin-resistant cell lines, both conditions that are challenging to treat Almost all mammalian cells contain IP 6 and much smaller amounts of its forms with fewer phosphate groups IPwhich are important for regulating vital cellular functions. However, IP 6 causes the accumulation of human leukemia cells in the G 2 M phase of the cell cycle; a cDNA microarray analysis showed a down-modulation of multiple genes involved in transcription and cell-cycle regulation by IP 6 Its induction of terminal differentiation 262829323338restoration of immune response 59modulation of inosutol factors 58modulation of signal transduction pathways 15163557induction of apoptosis 253445and possibly inhibition iinositol oncogene activity and restoration of tumor suppressor function are well documented.

Additionally, when IP 6 plus inosifol was given in combination with chemotherapy, side effects of chemotherapy drop in leukocyte and platelet counts, nausea, vomiting, alopecia were diminished and patients were able to perform their daily activities Recently IP 6 has received much attention for its role in cancer prevention and control of experimental tumor inlsitol, progression, and metastasis.


Furthermore, IP 6 reduced O -tetradecanoylphorbolacetate—induced ornithine decarboxylase activity, an inositoo event in tumor promotion in HEL cells, a murine keratinocyte cell line However, recent studies demonstrate that this antinutrient effect of IP 6 can be manifested only when large quantities of IP 6 are consumed in combination with a diet poor in oligoelements 60 — Inositol hexaphosphate IP 6 is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells.

An antagonist of fibroblast growth factor receptor binding and activity. IP 6 significantly reduced experimental mammary carcinoma in Sprague-Dawley rats induced either by 7,dimethylbenz[ a ]anthracene 51 i6 54 or N -methylnitrosourea Effect of fiber, phytic acid, and oxalic acid in the diet on mineral bioavailability.

IP 6 can also modulate cellular response at the level of receptor binding. Therefore, the strategy of chemoprevention is to use agents that inosltol inhibit mutagenesis, induce apoptosis, induce maturation and differentiation, and inhibit proliferation Novel anticancer function of inositol hexaphosphate IP 6: Synergistic cancer inhibition by IP 6 when combined with inositol Ins 1,2-dimethylhydrazine DMH – induced colon carcinoma in mice.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

IP 6 can regulate the cell cycle to block uncontrolled cell division and force malignant cells either to differentiate or go into apoptosis. For a long time IP 6 has been recognized as a natural antioxidant. IP 6 was administered orally either as the pure sodium salt or in a diet to reduce hypercalciuria and to prevent formation of kidney stones, and no evidence of toxicity was reported 646579 Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice.

Intra-tumoral injection of IP 6 regresses pre-existing human liver cancer xenotransplanted in nude mice.

I6p 6 inhibits phosphatidylinositol-3 kinase Malignant and normal cells are known to have a different metabolism, growth rate, expression of receptors, etc. IP 6 induces G 1 phase arrest and a significant decrease of the S phase of human breast 6869colon 69and prostate 34 cancer cell lines. Enhanced immunity and antioxidant properties can also contribute to tumor cell destruction.

Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP6 holds great promise in our strategies for the prevention and treatment of cancer. Using highly invasive MDA-MB human breast cancer cells, we demonstrated that IP 6 inhibits metastasis in vitro through effects inostol cancer cell op6, migration, and invasion 70 Only myo -inositol hexaphosphate has been found in plants; neo – chiro – and scyllo -inositol hexaphosphates have been isolated from soil 7.


Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Exogenously administered IP6 is rapidly taken into the cells and dephosphorylated to lower-phosphate inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. However, because cancer prevention is a long process, a long administration of cancer preventive agent is generally needed, requiring usually 10—40 y of continuous treatment 273and, therefore, it is very important that cancer preventive agents have low or almost no inosirol.

Besides affecting tumor cells, IP 6 can act on a host by restoring its immune system.

IP 6 inhibits agonist-induced platelet aggregation 82 and efficiently protects myocardium from ischemic damage and reperfusion injury 83both of which are important for the management of cardiovascular diseases.

One patient with liver metastasis refused chemotherapy after the inosifol treatment, and she was treated only with IP 6 plus inositol; her control ultrasound and abdominal computed tomography scan 14 mo after surgery showed a significantly reduced growth rate.

Protection against cancer by dietary IP6 and inositol.

Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP 6 holds great promise in our strategies for the prevention i;6 treatment of cancer.

The antiproliferative activity of IP 6 was further reported in human colon cancer HT cells 28estrogen receptor—positive and estrogen receptor—negative human breast cancer cells 32cervical cancer 25prostate cancer 153334and HepG2 hepatoma cell lines However, cells from different origin have different sensitivity to IP 6 the leukemic cell lines seem to be highly susceptible to IP 6suggesting that IP 6 may affect different cell types through different mechanisms of action.

Sign In or Create an Account. Although IP 6 may belong to almost all previously mentioned categories of cancer preventive drugs, affecting almost all phases of cancer prevention, it still appears that IP 6 is not a direct antagonist to the carcinogen inosiotl of its moderate efficacy inosittol vitro when tested and compared with other chemopreventive inosiitol 30 and a lack of dramatic decrease in cancer incidence when tested in vivo.

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